Article
Human leukocyte antigen polymorphisms in Italian primary biliary cirrhosis: a multicenter study of 664 patients and 1992 healthy controls.
Hepatology (Baltimore, Md.) - 1 Dec 2008
Invernizzi Pietro, Selmi Carlo, Poli Francesca, Frison Sara, Floreani Annarosa, Alvaro Domenico, Almasio Piero, Rosina Floriano, Marzioni Marco, Fabris Luca, Muratori Luigi, Qi Lihong, Seldin Michael F, Gershwin M Eric, Podda Mauro
Abstract excerpt
Genetic factors are critical in determining susceptibility to primary biliary cirrhosis (PBC), but there has not been a clear association with human leukocyte antigen (HLA) genes. We performed a multicenter case-control study and analyzed HLA class II DRB1 associations using a large cohort of 664 well-defined cases of PBC and 1992 controls of Italian ancestry. Importantly, healthy controls were rigorously matched...
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