Article
Genetic susceptibility to primary biliary cirrhosis.
European journal of gastroenterology & hepatology - 1 Jun 1999
Agarwal K, Jones D E, Bassendine M F
Abstract excerpt
Family studies suggest that genetic factors play a role in determining susceptibility to primary biliary cirrhosis (PBC). A number of polymorphic genes with small and additive effects may thus encode factors predisposing to this 'polygenic' disease. All the published data on genetic predisposition to PBC have been obtained from association studies, based on comparison of the frequency of an allele in unrelated...
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