Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TNF-alpha polymorphisms in primary biliary cirrhosis: a northern and southern Italian experience.

Annals of the New York Academy of Sciences - 1 Sept 2009

Niro Grazia Anna, Poli Francesca, Andriulli Angelo, Bianchi Ilaria, Bernuzzi Francesca, Caliari Lisa, Fontana Rosanna, Gioffreda Domenica, Valvano Maria Rosa, Podda Mauro, Invernizzi Pietro

Abstract excerpt

Specific HLA alleles and immunoregulatory genes have been evaluated in primary biliary cirrhosis (PBC), but data are discordant. We determined whether TNF-alpha promoter polymorphisms (G-308A and G-238A) and alleles of HLA class II (HLA-DRB1) might be associated either with PBC occurrence and severity in Italian populations from two distinct areas. The distribution of TNF1 (G/G) genotype did not differ either...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Progression
Share to Geography

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HLA-DR Antigens

Share to HLA-DRB1 Chains

Share to Liver Cirrhosis, Biliary

Share to Promoter Regions, Genetic

Share to Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 19758199
DOI: 10.1111/j.1749-6632.2009.04741.x

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TNF-alpha polymorphisms in primary biliary cirrhosis: a northern and southern Italian experience.PMID 19758199Read ↗

Meta-analysis: the relationship between TNF-alpha polymorphisms and susceptibility to primary biliary cirrhosis.Semantic proximity Read ↗

Tumour necrosis factor-alpha promoter polymorphisms in primary biliary cirrhosis.Semantic proximity Read ↗

Primary biliary cirrhosis shows association with genetic polymorphism of tumour necrosis factor alpha promoter region.Semantic proximity Read ↗

Analysis of major histocompatibility complex and CTLA-4 alleles in Brazilian patients with primary biliary cirrhosis.Semantic proximity Read ↗

The tumor necrosis factor-alpha promoter correlates with progression of primary biliary cirrhosis.Semantic proximity Read ↗

Effect of the polymorphisms of tumor necrosis factor-α gene on the susceptibility to primary biliary cirrhosis: a meta-analysis.Semantic proximity Read ↗

Allelic variation in the TNF-beta gene does not explain the low TNF-beta response in patients with primary biliary cirrhosis.Semantic proximity Read ↗

Human leukocyte antigen polymorphisms in Italian primary biliary cirrhosis: a multicenter study of 664 patients and 1992 healthy controls.Semantic proximity Read ↗

HLA class II alleles, genotypes, haplotypes, and amino acids in primary biliary cirrhosis: a large-scale study.Semantic proximity Read ↗

Novel association of HLA-haplotypes with primary sclerosing cholangitis (PSC) in a southern European population.Semantic proximity Read ↗

Carriage of a tumor necrosis factor polymorphism amplifies the cytotoxic T-lymphocyte antigen 4 attributed risk of primary biliary cirrhosis: evidence for a gene-gene interaction.Semantic proximity Read ↗

[Genetic association of tumor necrosis factor (TNF)-alpha polymorphisms with primary biliary cirrhosis and autoimmune liver diseases in a Chinese population].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.