Article
Analysis of HLA alleles polymorphism in Chinese patients with primary biliary cirrhosis.
Hepatobiliary & pancreatic diseases international : HBPD INT - 1 Feb 2006
Liu Hai-Ying, Deng An-Mei, Zhou Ye, Yao Ding-Kang, Xu De-Xing, Zhong Ren-Qian
Abstract excerpt
BACKGROUND: A familial clustering of patients with primary biliary cirrhosis (PBC) and the presence of immunological abnormalities in family members suggest a genetic component involved in the pathogenesis of PBC. The aims of this study are to investigate the frequencies of human leukocyte antigen HLA-A, -B, and -DRB1 alleles in Chinese patients with PBC by polymerase chain reaction (PCR)-based techniques, and to...
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