Article
The upstream open reading frame mediates constitutive effects on translation of cytochrome p-450c27 from the seventh in-frame AUG codon in rat liver.
The Journal of biological chemistry - 17 Oct 2003
Lodhi Khalid M, Ozdener Mehmet H, Shayiq Rass M
Abstract excerpt
The 2.3-kb mRNA that codes for cytochrome P-450c27 (CYP27) has an unexpectedly long 5'-untranslated region (UTR) that holds six AUGs, leading to several upstream open reading frames (uORFs). The initiation of translation from the seventh AUG forms a putative 55-kDa precursor, which is processed i...
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