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CYP2D7 splice variants in human liver and brain: does CYP2D7 encode functional protein?

Biochemical and biophysical research communications - 4 Nov 2005

Gaedigk Andrea, Gaedigk Roger, Leeder J Steven

Abstract excerpt

A CYP2D7 brain-specific protein metabolizing codeine and encoded by an alternate mRNA has recently been described in Indian subjects. To examine its potential presence in other ethnic backgrounds, CYP2D7 and CYP2D6 full-length splice products were analyzed in liver and brain. CYP2D7 splice variant-specific PCR on 13 subjects revealed the previously reported partial intron 6-containing transcript encoding CYP2D7...

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Identifiers

PMID: 16169517
DOI: 10.1016/j.bbrc.2005.08.255

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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