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Article

Distinctive Properties of the 5′-Untranslated Region of Human Hsp70 mRNA

1 Jun 2003

Abstract excerpt

A relaxed cap-dependence of translation of the mRNA-encoding mammalian heat shock protein Hsp70 may suggest that its 5'-untranslated region (UTR) possesses an internal ribosome entry site (IRES). In this study, this possibility has been tested in transfected cells using plasmids that express dicistronic mRNAs. Using a reporter gene construct, Renilla luciferase/Photinus pyralis luciferase, we show that the 216-nt...

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PMID: 12682055
DOI: 10.1074/jbc.m303213200

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