Article
Translation initiation in Drosophila melanogaster is reduced by mutations upstream of the AUG initiator codon.
Molecular and cellular biology - 1 Apr 1991
Feng Y, Gunter L E, Organ E L, Cavener D R
Abstract excerpt
The importance to in vivo translation of sequences immediately upstream of the Drosophila alcohol dehydrogenase (Adh) start codon was examined at two developmental stages. Mutations were introduced into the Adh gene in vitro, and the mutant gene was inserted into the genome via germ line transformation. An A-to-T substitution at the -3 position did not affect relative translation rates of the ADH protein at the...
Topics
- Alcohol Dehydrogenase
- Animals
- Base Sequence
- Codon
- Drosophila melanogaster
- Genes
- Molecular Sequence Data
- Mutation
- Protein Biosynthesis
- Transformation, Genetic