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Article

Lipopolysaccharide stimulates mitochondrial biogenesis via activation of nuclear respiratory factor-1.

The Journal of biological chemistry - 17 Oct 2003

Suliman Hagir B, Carraway Martha S, Welty-Wolf Karen E, Whorton A Richard, Piantadosi Claude A

Abstract excerpt

Exposure to bacterial lipopolysaccharide (LPS) in vivo damages mitochondrial DNA (mtDNA) and interferes with mitochondrial transcription and oxidative phosphorylation (OXPHOS). Because this damage accompanies oxidative stress and is reversible, we postulated that LPS stimulates mtDNA replication and mitochondrial biogenesis via expression of factors responsive to reactive oxygen species, i.e. nuclear respiratory...

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Identifiers

PMID: 12902348
DOI: 10.1074/jbc.M304719200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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