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Article

Role of SIRT1 in regulation of LPS- or two ethanol metabolites-induced TNF-alpha production in cultured macrophage cell lines.

American journal of physiology. Gastrointestinal and liver physiology - 1 May 2009

Shen Zheng, Ajmo Joanne M, Rogers Christopher Q, Liang Xiaomei, Le Lisa, Murr Michel M, Peng Yanhua, You Min

Abstract excerpt

Dysregulation of proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) has been implicated in the pathogenesis of alcoholic liver injury. Sirtuin 1 (SIRT1) is an NAD(+)-dependent class III protein deacetylase that is known to be involved in regulating production of proinflammatory cytokines including TNF-alpha. In the present study, we examined the role of SIRT1 signaling in TNF-alpha...

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Source

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Identifiers

PMID: 19299582
DOI: 10.1152/ajpgi.00016.2009
PMCID: PMC2696216

Genes

SIRT1
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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