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Article

Elevated mitochondrial reactive oxygen species generation affects the immune response via hypoxia-inducible factor-1alpha in long-lived Mclk1+/- mouse mutants.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2010

Wang Dantong, Malo Danielle, Hekimi Siegfried

Abstract excerpt

Mitochondrial reactive oxygen species (ROS) are believed to stabilize hypoxia-inducible factor (HIF)-1alpha, a transcriptional regulator of the immune response. Mclk1 encodes a mitochondrial protein that is necessary for ubiquinone biosynthesis. Heterozygote Mclk1(+/-) mutant mice are long-lived despite increased mitochondrial ROS and decreased energy metabolism. In this study, Mclk1(+/-) mutant mice in the...

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PMID: 20007531
DOI: 10.4049/jimmunol.0902352

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TNF

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