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Article

Redox regulation of lipopolysaccharide-mediated sulfiredoxin induction, which depends on both AP-1 and Nrf2.

The Journal of biological chemistry - 5 Nov 2010

Kim Hojin, Jung Yuyeon, Shin Bong Soo, Kim Hyeryeon, Song Hyunsook, Bae Soo Han, Rhee Sue Goo, Jeong Woojin

Abstract excerpt

Sulfiredoxin (Srx) is an enzyme that catalyzes the reduction of cysteine sulfinic acid of hyperoxidized peroxiredoxins and exerts a protective antioxidant role. Here we investigated the regulatory mechanism of Srx induction by lipopolysaccharide (LPS) in mouse macrophages. LPS up-regulated Srx expression on the transcriptional level. The promoter region of the Srx gene contained putative NF-κB and AP-1 (activator...

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Identifiers

PMID: 20826812
DOI: 10.1074/jbc.M110.126839
PMCID: PMC2966056

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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