Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Imbalance in mitochondrial dynamics induced by low PGC-1α expression contributes to hepatocyte EMT and liver fibrosis

8 Apr 2020

Abstract excerpt

Abstract An imbalance in mitochondrial dynamics induced by oxidative stress may lead to hepatocyte epithelial mesenchymal transition (EMT) and liver fibrosis. However, the underlying molecular mechanisms have not been fully elucidated. This study investigated the role of mitochondrial dynamics in hepatocyte EMT and liver fibrosis using an in vitro human (L-02 cells, hepatic cell line) and an in vivo mouse model...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP Synthase and ATPases Research
Share to Liver Disease Diagnosis and Treatment
Share to Mitochondrial Function and Pathology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32269221
DOI: 10.1038/s41419-020-2429-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Imbalance in mitochondrial dynamics induced by low PGC-1α expression contributes to hepatocyte EMT and liver fibrosisPMID 32269221Read ↗

Mitochondrial dysfunction and liver disease: role, relevance, and potential for therapeutic modulationSemantic proximity Read ↗

Hepatocyte Mitochondrial Dynamics and Bioenergetics in Obesity-Related Non-Alcoholic Fatty Liver DiseaseSemantic proximity Read ↗

Circadian gene Clock regulates mitochondrial morphology and functions by posttranscriptional waySemantic proximity Read ↗

Decreasing mitochondrial fission prevents cholestatic liver injury.Semantic proximity Read ↗

Decreasing mitochondrial fission alleviates hepatic steatosis in a murine model of nonalcoholic fatty liver disease.Semantic proximity Read ↗

<i>Mtfp1</i> ablation enhances mitochondrial respiration and protects against hepatic steatosisSemantic proximity Read ↗

Activation of the Mitochondrial Apoptotic Pathway Produces Reactive Oxygen Species and Oxidative Damage in Hepatocytes That Contribute to Liver TumorigenesisSemantic proximity Read ↗

Dynamin-related protein 1 deficiency impairs mitophagy and accelerates lipopolysaccharide-induced inflammation in miceSemantic proximity Read ↗

Ketogenic Diet Ameliorates NAFLD via Balancing Mitochondrial Dynamics and Improving Mitochondrial DysfunctionSemantic proximity Read ↗

Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseasesSemantic proximity Read ↗

Acrolein induces mtDNA damages, mitochondrial fission and mitophagy in human lung cellsSemantic proximity Read ↗

Peroxisomes control mitochondrial dynamics and the mitochondrion-dependent pathway of apoptosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.