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Article

Lipopolysaccharide-induced heme oxygenase-1 expression in human monocytic cells is mediated via Nrf2 and protein kinase C.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2005

Rushworth Stuart A, Chen Xi-Lin, Mackman Nigel, Ogborne Richard M, O'Connell Maria A

Abstract excerpt

Monocytes play a key role in mobilization of the immune response during sepsis. In response to LPS, monocytes produce both proinflammatory mediators and regulatory proteins that counteract the inflammation and oxidative stress. In murine macrophages, LPS stimulates expression of heme oxygenase 1 (HO-1), a cytoprotective enzyme that catalyzes the degradation of heme. The HO-1 5'-untranslated region, similarly to...

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Identifiers

PMID: 16177082
DOI: 10.4049/jimmunol.175.7.4408

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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