Mitochondrial biogenesis fails in secondary biliary cirrhosis in rats leading to mitochondrial DNA depletion and deletions

Abstract excerpt

Chronic cholestasis is characterized by mitochondrial dysfunction, associated with loss of mitochondrial membrane potential, decreased activities of respiratory chain complexes, and ATP production. Our aim was to determine the molecular mechanisms that link long-term cholestasis to mitochondrial dysfunction. We studied a model of chronic cholestasis induced by bile duct ligation in rats. Key sensors and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Liver Disease Diagnosis and Treatment
• Share to Metabolism and Genetic Disorders
• Share to Mitochondrial Function and Pathology