Article
The conserved Nup107-160 complex is critical for nuclear pore complex assembly.
Cell - 18 Apr 2003
Walther Tobias C, Alves Annabelle, Pickersgill Helen, Loïodice Isabelle, Hetzer Martin, Galy Vincent, Hülsmann Bastian B, Köcher Thomas, Wilm Matthias, Allen Terry, Mattaj Iain W, Doye Valérie
Abstract excerpt
Nuclear pore complexes (NPCs) are large multiprotein assemblies that allow traffic between the cytoplasm and the nucleus. During mitosis in higher eukaryotes, the Nuclear Envelope (NE) breaks down and NPCs disassemble. How NPCs reassemble and incorporate into the NE upon mitotic exit is poorly understood. We demonstrate a function for the conserved Nup107-160 complex in this process. Partial in vivo depletion of...
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