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Article

Functional significance of a hereditary adenine insertion variant in the 5'-UTR of the endothelin-1 gene.

Pharmacogenetics - 1 Aug 2003

Popowski Katrin, Sperker Bernhard, Kroemer Heyo K, John Ulrich, Laule Michael, Stangl Karl, Cascorbi Ingolf

Abstract excerpt

Endothelin-1 (ET-1) is known as a potent vasoconstrictor peptide and stimulator of cell proliferation. The human preproendothelin-1 mRNA contains a frequent adenine insertion polymorphism (allele frequency = 0.28) within the 5'-untranslated region (5'-UTR), 138 bp downstream of the transcription start site, which was assumed to be related to hypertension. This 5'-UTR variant could putatively influence the mRNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 12893982
DOI: 10.1097/00008571-200308000-00002

Genes

GAPDH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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