Article

Common variation in <i>EDN1</i> regulatory regions highlights the role of PPARγ as a key regulator of Endothelin <i>in vitro</i>

2021-11-19

Abstract excerpt

Pulmonary Arterial Hypertension (PAH) is a rare disease caused by the obliteration of the pulmonary arterioles, increasing pulmonary vascular resistance and eventually causing right heart failure. Endothelin-1 is a vasoconstrictor peptide whose levels are indicators of disease progression and its pathway is one of the commonest targeted by current treatments. We sequenced the EDN1 untranslated regions of a small...

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Literature Corpus work: d8b67dda-2987-5c8d-8835-81b9b77548ee
DOI: 10.1101/2021.11.18.468847

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