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Article

Influence of an insertion variant in the 5'UTR of the endothelin-1 gene on orthostatic intolerance.

The American journal of the medical sciences - 1 Oct 2005

Winker Robert, Garland Emily M, Rüdiger Hugo W, Diedrich André, Biaggioni Italo, Ponocny Ivo, Cascorbi Ingolf, Robertson David

Abstract excerpt

BACKGROUND: Orthostatic intolerance is a multifactorial disease in which the genetic contribution is probably the result of a number of genes acting in combination. Recent work has shown that orthostatic intolerance is influenced by endothelial nitric oxide synthase gene polymorphisms. Since endothelin-1 (ET-1) is one of the most important vasoconstrictor peptides, a frequent adenine insertion polymorphism within...

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PMID: 16234608
DOI: 10.1097/00000441-200510000-00003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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