Article
Target sequencing, cell experiments, and a population study establish endothelial nitric oxide synthase (eNOS) gene as hypertension susceptibility gene.
Hypertension (Dallas, Tex. : 1979) - 1 Nov 2013
Salvi Erika, Kuznetsova Tatiana, Thijs Lutgarde, Lupoli Sara, Stolarz-Skrzypek Katarzyna, D'Avila Francesca, Tikhonoff Valerie, De Astis Silvia, Barcella Matteo, Seidlerová Jitka, Benaglio Paola, Malyutina Sofia, Frau Francesca, Velayutham Dinesh, Benfante Roberta, Zagato Laura, Title Alexandra, Braga Daniele, Marek Diana, Kawecka-Jaszcz Kalina, Casiglia Edoardo, Filipovsky Jan, Nikitin Yuri, Rivolta Carlo, Manunta Paolo, Beckmann Jacques S, Barlassina Cristina, Cusi Daniele, Staessen Jan A
Abstract excerpt
A case-control study revealed association between hypertension and rs3918226 in the endothelial nitric oxide synthase (eNOS) gene promoter (minor/major allele, T/C allele). We aimed at substantiating these preliminary findings by target sequencing, cell experiments, and a population study. We sequenced the 140-kb genomic area encompassing the eNOS gene. In HeLa and HEK293T cells transfected with the eNOS promoter...
Read the complete abstract on PubMed