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Article

Identification of a novel polymorphism in the 3'UTR of the L-arginine transporter gene SLC7A1: contribution to hypertension and endothelial dysfunction.

Circulation - 13 Mar 2007

Yang Zhiyong, Venardos Kylie, Jones Emma, Morris Brian J, Chin-Dusting Jaye, Kaye David M

Abstract excerpt

BACKGROUND: Endothelial dysfunction because of reduced nitric oxide bioavailability is a key feature of essential hypertension. We have found that normotensive siblings of subjects with essential hypertension have impaired endothelial function accompanied by altered arginine metabolism. METHODS AND RESULTS: We have identified a novel C/T polymorphism in the 3'UTR of the principal arginine transporter, solute...

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PMID: 17325243
DOI: 10.1161/CIRCULATIONAHA.106.665836

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