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Article

Quantitative lymphatic vessel trait analysis suggests Vcam1 as candidate modifier gene of inflammatory bowel disease.

Genes and immunity - 1 Apr 2010

Jurisic G, Sundberg J P, Bleich A, Leiter E H, Broman K W, Buechler G, Alley L, Vestweber D, Detmar M

Abstract excerpt

Inflammatory bowel disease (IBD) is a chronic debilitating disease resulting from a complex interaction of multiple genetic factors with the environment. To identify modifier genes of IBD, we used an F2 intercross of IBD-resistant C57BL/6J-Il10(-/-) mice and IBD-susceptible C3H/HeJBir-Il10(-/-) (C3Bir-Il10(-/-)) mice. We found a prominent involvement of lymphatic vessels in IBD and applied a scoring system to...

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Source

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Identifiers

PMID: 20220769
DOI: 10.1038/gene.2010.4
PMCID: PMC2865135

Genes

VCAM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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