Article
Identification of novel loci controlling inflammatory bowel disease susceptibility utilizing the genetic diversity of wild-derived mice.
Genes and immunity - 1 Nov 2020
Lahue Karolyn G, Lara Montana K, Linton Alisha A, Lavoie Brigitte, Fang Qian, McGill Mahalia M, Crothers Jessica W, Teuscher Cory, Mawe Gary M, Tyler Anna L, Mahoney J Matthew, Krementsov Dimitry N
Abstract excerpt
Inflammatory bowel disease (IBD) is a complex disorder that imposes a growing health burden. Multiple genetic associations have been identified in IBD, but the mechanisms underlying many of these associations are poorly understood. Animal models are needed to bridge this gap, but conventional laboratory mouse strains lack the genetic diversity of human populations. To more accurately model human genetic...
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