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Article

The BDNF Val66Met polymorphism has opposite effects on memory circuits of multiple sclerosis patients and controls.

PloS one - 1 Jan 2013

Fera Francesco, Passamonti Luca, Cerasa Antonio, Gioia Maria Cecilia, Liguori Maria, Manna Ida, Valentino Paola, Quattrone Aldo

Abstract excerpt

Episodic memory deficits are frequent symptoms in Multiple Sclerosis and have been associated with dysfunctions of the hippocampus, a key region for learning. However, it is unclear whether genetic factors that influence neural plasticity modulate episodic memory in MS. We thus studied how the Brain Derived Neurotrophic Factor Val(66)Met genotype, a common polymorphism influencing the hippocampal function in...

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Identifiers

PMID: 23593393
DOI: 10.1371/journal.pone.0061063
PMCID: PMC3623818

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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