Article
BDNF polymorphism rs6265 and hippocampal structure and memory performance in healthy control subjects.
Psychiatry research - 30 Jul 2010
Karnik Meghana S, Wang Lei, Barch Deanna M, Morris John C, Csernansky John G
Abstract excerpt
Brain-derived neurotrophic factor (BDNF) is highly expressed in the hippocampus of many species, including humans. The single-nucleotide polymorphism rs6265 on the BDNF gene is thought to alter activity-dependent secretion of the protein, and previous research suggests that the Met allele is associated with smaller hippocampal volumes and poorer memory performance in human populations. For this study, we...
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