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Article

Dose-dependent effect of the Val66Met polymorphism of the brain-derived neurotrophic factor gene on memory-related hippocampal activity.

Neuroscience research - 1 Aug 2008

Hashimoto Ryota, Moriguchi Yoshiya, Yamashita Fumio, Mori Takeyuki, Nemoto Kiyotaka, Okada Takeya, Hori Hiroaki, Noguchi Hiroko, Kunugi Hiroshi, Ohnishi Takashi

Abstract excerpt

Brain-derived neurotrophic factor (BDNF) plays a critical role in activity-dependent neuroplasticity underlying learning and memory in the hippocampus. Recent human studies have indicated that a common single nucleotide polymorphism of the BDNF gene, the Val66Met polymorphism, has impact on episodic memory, hippocampal morphology and memory-related hippocampal activity measured by functional magnetic resonance...

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Source

Identifiers

PMID: 18501457
DOI: 10.1016/j.neures.2008.04.003

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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