Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Roles for homotypic interactions and transautophosphorylation in IkappaB kinase beta IKKbeta) activation [corrected].

The Journal of biological chemistry - 3 Oct 2003

Tang Eric D, Inohara Naohiro, Wang Cun-Yu, Nuñez Gabriel, Guan Kun-Liang

Abstract excerpt

The nuclear factor kappaB (NF-kappaB)/Rel family of transcription factors participates in a wide range of biological activities including inflammation, immunity, and apoptosis. NF-kappaB is kept inactive in the cytoplasm in unstimulated cells by virtue of the masking of its nuclear localization sequence by bound IkappaB protein. Cellular stimuli trigger the destruction of IkappaB proteins and the liberation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Enzyme Activation
Share to Genetic Vectors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to I-kappa B Kinase

Share to Leucine

Share to Ligands

Share to NF-kappa B

Share to Precipitin Tests

Share to Serine

Source

Identifiers

PMID: 12890679
DOI: 10.1074/jbc.M304374200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Roles for homotypic interactions and transautophosphorylation in IkappaB kinase beta IKKbeta) activation [corrected].PMID 12890679Read ↗

Site-specific monoubiquitination of IkappaB kinase IKKbeta regulates its phosphorylation and persistent activation.Semantic proximity Read ↗

Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation.Semantic proximity Read ↗

Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate.Semantic proximity Read ↗

Tyrosine phosphorylation is required for IkappaB kinase-beta (IKKbeta) activation and function in osteoclastogenesis.Semantic proximity Read ↗

Hypo-phosphorylation leads to nuclear retention of NF-kappaB p65 due to impaired IkappaBalpha gene synthesis.Semantic proximity Read ↗

Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation.Semantic proximity Read ↗

Suppression of p65 phosphorylation coincides with inhibition of IkappaBalpha polyubiquitination and degradation.Semantic proximity Read ↗

Essential role of IkappaB kinase alpha in thymic organogenesis required for the establishment of self-tolerance.Semantic proximity Read ↗

Activation of the heterodimeric IkappaB kinase alpha (IKKalpha)-IKKbeta complex is directional: IKKalpha regulates IKKbeta under both basal and stimulated conditions.Semantic proximity Read ↗

The NF-κB regulator IκBβ exhibits different molecular interactivity and phosphorylation status from IκBα in an IKK2-catalysed reaction.Semantic proximity Read ↗

The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis.Semantic proximity Read ↗

Positive regulation of IkappaB kinase signaling by protein serine/threonine phosphatase 2A.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.