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Article

Positive regulation of IkappaB kinase signaling by protein serine/threonine phosphatase 2A.

The Journal of biological chemistry - 28 Oct 2005

Kray Arlene E, Carter Robert S, Pennington Kevin N, Gomez Rey J, Sanders Laura E, Llanes Joan M, Khan Wasif N, Ballard Dean W, Wadzinski Brian E

Abstract excerpt

Transcription factor NF-kappaB plays a key regulatory role in the cellular response to pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF). In the absence of TNF, NF-kappaB is sequestered in the cytoplasm by inhibitory IkappaB proteins. Phosphorylation of IkappaBby the beta-catalytic subunit of IKK, a multicomponent IkappaB kinase, targets the inhibitor for proteolytic destruction and facilitates...

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PMID: 16126728
DOI: 10.1074/jbc.M506093200

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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