Article
The NF-κB regulator IκBβ exhibits different molecular interactivity and phosphorylation status from IκBα in an IKK2-catalysed reaction.
FEBS letters - 1 May 2020
Shoji Shisako, Hanada Kazuharu, Takahashi Masataka, Watanabe Kazuhide, Yonemochi Mayumi, Tomabechi Yuri, Shirouzu Mikako
Abstract excerpt
Activation of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) transcription factor, a central player in immune response regulation, is based on phosphorylation of inhibitor of kappaB alpha (IκBα) by the Inhibitor of kappaB kinase (IKK) that triggers IκBα degradation. Although inhibitor of kappaB beta (IκBβ) is structurally similar to IκBα, its precise characteristics remain undefined....
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