Article
Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate.
Science (New York, N.Y.) - 28 Aug 1998
Zandi E, Chen Y, Karin M
Abstract excerpt
A large protein complex mediates the phosphorylation of the inhibitor of kappaB (IkappaB), which results in the activation of nuclear factor kappaB (NF-kappaB). Two subunits of this complex, IkappaB kinase alpha (IKKalpha) and IkappaB kinase beta (IKKbeta), are required for NF-kappaB activation....
Topics
- Animals
- Cell Line
- Dimerization
- Enzyme Activation
- HeLa Cells
- Helix-Loop-Helix Motifs
- Humans
- I-kappa B Kinase
- Leucine Zippers
- Mutation
- NF-kappa B
- Phosphorylation
- Protein Serine-Threonine Kinases
- Proto-Oncogene Proteins
- Recombinant Fusion Proteins
- Recombinant Proteins
- Spodoptera
- Transcription Factor RelB