Article
Neurological phenotype and synaptic function in mice lacking the CaV1.3 alpha subunit of neuronal L-type voltage-dependent Ca2+ channels.
Neuroscience - 1 Jan 2003
Clark N C, Nagano N, Kuenzi F M, Jarolimek W, Huber I, Walter D, Wietzorrek G, Boyce S, Kullmann D M, Striessnig J, Seabrook G R
Abstract excerpt
Neuronal L-type calcium channels have been implicated in pain perception and neuronal synaptic plasticity. To investigate this we have examined the effect of disrupting the gene encoding the CaV1.3 (alpha 1D) alpha subunit of L-type Ca2+ channels on neurological function, acute nociceptive behavior, and hippocampal synaptic function in mice. CaV1.3 alpha 1 subunit knockout (CaV1.3 alpha 1(-/-)) mice had...
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