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Migraine Mutations Impair Hippocampal Learning Despite Enhanced Long-Term Potentiation

25 Feb 2015

Abstract excerpt

To explain cognitive and memory difficulties observed in some familial hemiplegic migraine (FHM) patients, we examined hippocampal neurotransmission and plasticity in knock-in mice expressing the FHM type 1 (FHM1) R192Q gain-of function mutation in the CACNA1A gene that encodes the α1A subunit of neuronal CaV2.1 channels. We determined stimulus intensity-response curves for anterior commissure-evoked hippocampal...

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PMID: 25716839
DOI: 10.1523/jneurosci.2630-14.2015

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