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Article

Nerve Injury Induces Robust Allodynia and Ectopic Discharges in Na<sub>v</sub>1.3 Null Mutant Mice

1 Jan 2006

Abstract excerpt

Changes in sodium channel activity and neuronal hyperexcitability contribute to neuropathic pain, a major clinical problem. There is strong evidence that the re-expression of the embryonic voltage-gated sodium channel subunit Nav1.3 underlies neuronal hyperexcitability and neuropathic pain. Here we show that acute and inflammatory pain behaviour is unchanged in global Nav1.3 mutant mice. Surprisingly, neuropathic...

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PMID: 17052333
DOI: 10.1186/1744-8069-2-33

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