Article
A commonly deleted region in ovarian cancer on chromosome 19p13.3, not including the OAZ1 gene.
International journal of oncology - 1 Sept 2003
Yanaihara Nozomu, Okamoto Aikou, Matsufuji Senya
Abstract excerpt
Antizyme is a negative regulator of cellular polyamines. The gene for antizyme (OAZ1) is mapped to 19p13.3, where frequent allelic imbalance (AI) is observed in ovarian cancer. The potential role of antizyme 1 in ovarian carcinogenesis was addressed in this study. Mutations of the OAZ1 gene, including the entire coding region and associated promoter region, were examined in 50 primary ovarian tumors and 8 ovarian...
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