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Article

WWOX: a candidate tumor suppressor gene involved in multiple tumor types.

Proceedings of the National Academy of Sciences of the United States of America - 25 Sept 2001

Paige A J, Taylor K J, Taylor C, Hillier S G, Farrington S, Scott D, Porteous D J, Smyth J F, Gabra H, Watson J E

Abstract excerpt

We previously reported the construction of a P1-derived artificial chromosome (PAC) contig encompassing a set of homozygous deletions of chromosome 16q23-24.1 found in primary ovarian tumor material and several tumor cell lines. Using these PAC clones in a cDNA selection experiment, we have isolated a Sau3A fragment homologous to the WWOX transcript (GenBank accession no. ) from normal human ovarian surface...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11572989
DOI: 10.1073/pnas.191175898
PMCID: PMC58744

Genes

WWOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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WWOX: a candidate tumor suppressor gene involved in multiple tumor types.PMID 11572989Read ↗

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Alteration of WWOX in human cancer: a clinical view.Semantic proximity Read ↗

Deletion of the WWOX gene and frequent loss of its protein expression in human osteosarcomaSemantic proximity Read ↗

WWOX mRNA expression profile in epithelial ovarian cancer supports the role of WWOX variant 1 as a tumour suppressor, although the role of variant 4 remains unclearSemantic proximity Read ↗

Alternative transcripts of the candidate tumor suppressor gene, WWOX, are expressed at high levels in human breast tumorsSemantic proximity Read ↗

The supposed tumor suppressor gene WWOX is mutated in an early lethal microcephaly syndrome with epilepsy, growth retardation and retinal degeneration.Semantic proximity Read ↗

WWOX, tumour suppressor and modifier gene, as a regulator of gene expression and apoptosis in ovarian cancerSemantic proximity Read ↗

Identification of two candidate tumor suppressor genes on chromosome 17p13.3.Semantic proximity Read ↗

Characterization of the tumor suppressor gene <i>WWOX</i> in primary human oral squamous cell carcinomasSemantic proximity Read ↗

WWOX, the chromosomal fragile site FRA16D spanning gene: its role in metabolism and contribution to cancer.Semantic proximity Read ↗

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