Article
Allele-specific imbalance of oxidative stress-induced growth inhibitor 1 associates with progression of hepatocellular carcinoma.
Gastroenterology - 1 Apr 2014
Liu Ming, Li Yan, Chen Leilei, Chan Tim Hon Man, Song Yangyang, Fu Li, Zeng Ting-Ting, Dai Yong-Dong, Zhu Ying-Hui, Li Yan, Chen Juan, Yuan Yun-Fei, Guan Xin-Yuan
Abstract excerpt
BACKGROUND & AIMS: Although there are a few highly penetrant mutations that are linked directly to cancer initiation, more less-penetrant susceptibility alleles have been associated with cancer risk and progression. We used RNA sequence analysis to search for genetic variations associated with pathogenesis of hepatocellular carcinoma (HCC). METHODS: We analyzed 400 paired HCC and adjacent nontumor tissues, along...
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