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Article

High cholesterol affects platelet APP processing in controls and in AD patients.

Neurobiology of aging - 1 Sept 2003

Borroni Barbara, Colciaghi Francesca, Lenzi Gian Luigi, Caimi Luigi, Cattabeni Flaminio, Di Luca Monica, Padovani Alessandro

Abstract excerpt

Alzheimer disease (AD) is characterised by a decrease of platelet Amyloid Precursor Protein forms ratio (APPr), which parallels symptoms' severity. Recent studies have suggested that cholesterol might play a role in the pathophysiology of AD by modulating Abeta production. Aim of this study was to evaluate the relationship between serum cholesterol levels and platelet APP processing in controls and AD. Sixty AD...

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Source

Identifiers

PMID: 12885570
DOI: 10.1016/s0197-4580(02)00190-2

Genes

APP
CTRL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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