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Regulation of Cerebral Cholesterol Metabolism in Alzheimer Disease

1 Mar 2012

Abstract excerpt

Alzheimer disease (AD) is an age-related neurodegenerative disorder that manifests as a progressive loss of memory and deterioration of higher cognitive functions. Alzheimer disease is characterized by accumulation in the brain of the β-amyloid peptide generated by β- and γ-secretase processing of amyloid precursor protein. Epidemiological studies have linked elevated plasma cholesterol and lipoprotein levels in...

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PMID: 22367100
DOI: 10.2310/jim.0b013e318246d973

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