Article
Platelet dysfunction in hypercholesterolemia mice, two Alzheimer's disease mouse models and in human patients with Alzheimer's disease.
Biogerontology - 1 Aug 2015
Plagg Barbara, Marksteiner Josef, Kniewallner Kathrin M, Humpel Christian
Abstract excerpt
Alzheimer's disease (AD) is a severe neurodegenerative disorder characterized mainly by accumulation of amyloid-β plaques and neurofibrillary tangles, synaptic and neuronal loss. Blood platelets contain the neurotransmitter serotonin and amyloid-precursor protein (APP), and may thus be useful as...
Topics
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- Animals
- Apoptosis
- Biomarkers
- Blood Platelets
- Case-Control Studies
- Cross-Sectional Studies
- Disease Models, Animal
- Epidermal Growth Factor
- Female
- Genotype
- Humans
- Hyperlipidemias
- Male
- Mice, Transgenic