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Article

Altered amyloid protein processing in platelets of patients with Alzheimer disease.

Archives of neurology - 1 Feb 1997

Rosenberg R N, Baskin F, Fosmire J A, Risser R, Adams P, Svetlik D, Honig L S, Cullum C M, Weiner M F

Abstract excerpt

BACKGROUND: beta-Amyloid peptide, the core component of neuritic plaques in brain areas in patients with Alzheimer disease (AD), is 1 cleavage product of the beta-amyloid precursor protein (APP) in neurons and platelets. Alternate cleavage products of intact 140- to 150-kd APPs in platelets include nonamyloidogenic 120- to 130-kd and 110-kd isoforms. The possible differential significance of these 2 isoforms,...

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Source

Identifiers

PMID: 9041854
DOI: 10.1001/archneur.1997.00550140019007

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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