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Article

Alzheimer's disease: the cholesterol connection.

Nature neuroscience - 1 Apr 2003

Puglielli Luigi, Tanzi Rudolph E, Kovacs Dora M

Abstract excerpt

A hallmark of all forms of Alzheimer's disease (AD) is an abnormal accumulation of the beta-amyloid protein (Abeta) in specific brain regions. Both the generation and clearance of Abeta are regulated by cholesterol. Elevated cholesterol levels increase Abeta in cellular and most animals models of AD, and drugs that inhibit cholesterol synthesis lower Abeta in these models. Recent studies show that not only the...

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Identifiers

PMID: 12658281
DOI: 10.1038/nn0403-345

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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