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Article

Alzheimer's disease: the cholesterol connection.

Nature neuroscience - 1 Apr 2003

Puglielli Luigi, Tanzi Rudolph E, Kovacs Dora M

Abstract excerpt

A hallmark of all forms of Alzheimer's disease (AD) is an abnormal accumulation of the beta-amyloid protein (Abeta) in specific brain regions. Both the generation and clearance of Abeta are regulated by cholesterol. Elevated cholesterol levels increase Abeta in cellular and most animals models of...

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Identifiers

PMID: 12658281
DOI: 10.1038/nn0403-345

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12658281-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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