Article
Decreased platelet APP isoform ratios in autosomal dominant Alzheimer's disease: baseline data from a DIAN cohort subset.
Current Alzheimer research - 1 Jan 2015
Chatterjee Pratishtha, Gupta Veer B, Fagan Anne M, Jasielec Mateusz S, Xiong Chengjie, Sohrabi Hamid R, Dhaliwal Satvinder, Taddei Kevin, Bourgeat Pierrick, Brown Belinda M, Benzinger Tammie, Bateman Randall J, Morris John C, Martins Ralph N
Abstract excerpt
INTRODUCTION: This study examines platelet amyloid precursor protein (APP) isoform ratios of 120KDa to 110KDa (APPr) between mutation carriers (MC) carrying a mutation for autosomal dominant Alzheimer's disease (ADAD) and non-carriers (NC). Two previous studies reported no significant difference in APPr between ADAD MC and NC, which may have been due to the small sample size in both studies. The current study...
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