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Article

ApoE genotype influences the biological effect of donepezil on APP metabolism in Alzheimer disease: evidence from a peripheral model.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Jun 2002

Borroni Barbara, Colciaghi Francesca, Pastorino Lucia, Archetti Silvana, Corsini Paola, Cattabeni Flaminio, Di Luca Monica, Padovani Alessandro

Abstract excerpt

Three major amyloid precursor protein (APP) forms with apparent molecular weight ranging from 106 to 130 kDa are present in human platelets. Alzheimer disease (AD) is associated with a decreased APP forms ratio (APPr) between the three major forms. A total of 25 mild to moderate AD patients were investigated. Platelet APPr was studied before and after 30 days of acetylcholinesterase-inhibitor treatment...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12007670
DOI: 10.1016/s0924-977x(02)00013-5

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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