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Article

Brain cortical cholesterol metabolism is highly affected by human APP overexpression in mice.

Molecular and cellular neurosciences - 1 Jul 2016

Löffler Tina, Schweinzer Cornelia, Flunkert Stefanie, Sántha Miklós, Windisch Manfred, Steyrer Ernst, Hutter-Paier Birgit

Abstract excerpt

Processing of the amyloid precursor protein (APP) and amyloid beta (Aβ) has been for decades in the center of Alzheimer's disease (AD) research. Beside many other variables, lipids, especially cholesterol and its derivatives, are discussed to contribute to AD pathogenesis. Several studies show that cholesterol affects APP metabolism. Also the converse mechanism, the direct influence of Aβ on cholesterol...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27013422
DOI: 10.1016/j.mcn.2016.03.004

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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