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Article

Using motif-based methods in multiple genome analyses: a case study comparing orthologous mesophilic and thermophilic proteins.

Biochemistry - 5 Aug 2003

La David, Silver Melanie, Edgar Robert C, Livesay Dennis R

Abstract excerpt

Protein motifs represent highly conserved regions within protein families and are generally accepted to describe critical regions required for protein stability and/or function. In this comprehensive analysis, we present a robust, unique approach to identify and compare corresponding mesophilic and thermophilic sequence motifs between all orthologous proteins within 44 microbial genomes. Motif similarity is...

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PMID: 12885231
DOI: 10.1021/bi027435e

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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