Article

De novo discovery of conserved gene clusters in microbial genomes with Spacedust

2024-10-03

Abstract excerpt

Metagenomics has revolutionized environmental and human-associated microbiome studies. However, the limited fraction of proteins with known biological process and molecular functions presents a major bottleneck. In prokaryotes and viruses, evolution favors keeping genes participating in the same biological processes co-localized as conserved gene clusters. Conversely, conservation of gene neighborhood indicates fu...

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Literature Corpus work: ec96d074-3a3a-5fad-94ae-0f58e04a6ab3
DOI: 10.1101/2024.10.02.616292

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