Article
Integration of phenotypic metadata and protein similarity in Archaea using a spectral bipartitioning approach.
Nucleic acids research - 1 Apr 2009
Hooper Sean D, Anderson Iain J, Pati Amrita, Dalevi Daniel, Mavromatis Konstantinos, Kyrpides Nikos C
Abstract excerpt
In order to simplify and meaningfully categorize large sets of protein sequence data, it is commonplace to cluster proteins based on the similarity of those sequences. However, it quickly becomes clear that the sequence flexibility allowed a given protein varies significantly among different protein families. The degree to which sequences are conserved not only differs for each protein family, but also is...
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