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Article

Rapid Bioinformatic Identification of Thermostabilizing Mutations.

Biophysical journal - 6 Oct 2015

Sauer David B, Karpowich Nathan K, Song Jin Mei, Wang Da-Neng

Abstract excerpt

Ex vivo stability is a valuable protein characteristic but is laborious to improve experimentally. In addition to biopharmaceutical and industrial applications, stable protein is important for biochemical and structural studies. Taking advantage of the large number of available genomic sequences and growth temperature data, we present two bioinformatic methods to identify a limited set of amino acids or positions...

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Identifiers

PMID: 26445442
DOI: 10.1016/j.bpj.2015.07.026
PMCID: PMC4601007

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