Article
A novel scoring function for discriminating hyperthermophilic and mesophilic proteins with application to predicting relative thermostability of protein mutants.
BMC bioinformatics - 28 Jan 2010
Li Yunqi, Middaugh C Russell, Fang Jianwen
Abstract excerpt
BACKGROUND: The ability to design thermostable proteins is theoretically important and practically useful. Robust and accurate algorithms, however, remain elusive. One critical problem is the lack of reliable methods to estimate the relative thermostability of possible mutants. RESULTS: We report a novel scoring function for discriminating hyperthermophilic and mesophilic proteins with application to predicting...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.