Integrating Sequence, Structure, and Graph-based Features for Elucidating the Stability of Thermophilic Proteins.

Abstract excerpt

Proteins from thermophilic organisms exhibit remarkable stability under extreme thermal conditions. Understanding the molecular mechanisms underlying thermostability is essential for studying protein evolution and engineering robust enzymes. In this study, we systematically analyzed four sets of mesophilic-thermophilic protein pairs to investigate the molecular basis of thermal adaptation. We have constructed...

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